For many researchers, starting a company can be an exciting and immersive experience, however it is also one with heavy time and resource demands. As the majority of translational academic scientists will already have full time positions (either as staff of students), how can one run a company and maintain the high standard of work and dedication expected of their permanent position? Start-ups must be very dynamic and adaptable enterprises, and consequently the role of the founding scientist clearly changes dramatically over the time course of a company. Here we will look at the structure of a start-up and how this structure changes over time through the course of developing a start up from the early stages of just an idea, to an organisation gathering investment with a dedicated managerial team all the way to a profit making private or public company.

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